Author(s): Shoya Iwanami, Kosaku Kitagawa, Hirofumi Ohashi, Yusuke Asai, Koichi Watashi, Shingo Iwami
Title: A quantitative comparison between hepatitis C virus JFH-1 and Jc1 by a PDE multiscale model of virus infection.
Conference: 9th International Congress on Industrial and Applied Mathematics (ICIAM 2019)
Place: Valencia, Spain
Date: 2019年7月16日(火)


We developed a mathematical model of virus dynamics by partial differential equations which is multi-scale model to simultaneously describe intercellular virus infection and intracellular virus replication. We analyzed the experimental data of hepatitis C virus (HCV) JFH-1 and Jc1 infection in cell culture using the mathematical model and estimated parameters which described characteristics of HCV strains. As a result of comparison of estimated parameters, we found that JFH-1 strain had higher fitness than Jc1 strain.